TB Research

Ceftriaxone-induced thrombocytopenia during tuberculosis treatment: a case report.

Matthijs Plas, Linda M Kampschreur, Johannes A Kroes, Leendert Porcelijn, Carina Bethlehem

European journal of hospital pharmacy : science and practice · 2025-06

Abstract

We present a case of drug-induced immune thrombocytopenia (DITP) proven to be due to ceftriaxone instead of assumed tuberculostatic treatment in a patient with miliary tuberculosis. It is important to identify the culprit drug in DITP to avoid discontinuing essential treatment, especially when more than one drug is implicated. In these cases additional analysis (drug-dependent platelet antibody testing) should be considered to prevent unnecessary replacement of a first-line regimen of tuberculostatic treatment with an alternative treatment regime.

MeSH terms

  • Humans
  • Anti-Bacterial Agents
  • Antitubercular Agents
  • Ceftriaxone
  • Purpura, Thrombocytopenic, Idiopathic
  • Tuberculosis, Miliary