利福平联合异烟肼不同给药频次治疗初治活动性肺结核的疗效对比及安全性分析（Comparison of therapeutic efficacy and safety analysis of rifampicin combined with isoniazid at different dosing frequencies in the treatment of newly diagnosed active pulmonary tuberculosis）

Abstract：Objective: To explore the clinical efficacy and safety of different dosing frequencies of rifampicin combined with isoniazid in the treatment of newly diagnosed active pulmonary tuberculosis，and provide reference for optimizing clinical treatment plans. Method: 84 patients with newly diagnosed active pulmonary tuberculosis admitted to our hospital from January 2022 to January 2023 were selected as the research subjects. They were randomly divided into an observation group and a control group using a random number table method，with 42 patients in each group. The control group was given a once daily regimen of rifampicin combined with isoniazid，while the observation group was given an intermittent regimen of rifampicin combined with isoniazid three times a week. Compare the clinical efficacy （sputum conversion rate，lesion absorption rate，and cavity closure rate） of two groups of patients after 2 and 6 months of treatment，and record the occurrence of adverse reactions during the treatment period. Result: At 2 and 6 months of treatment，there was no statistically significant difference in sputum conversion rate，lesion absorption efficiency，and cavity closure rate between the two groups of patients （P>0.05）； There was no statistically significant difference in the incidence of adverse reactions between the two groups （P>0.05），and the adverse reactions were mainly gastrointestinal reactions and liver functionabnormalities，with mild to moderate severity. After symptomatic treatment，all reactions were relieved without affecting the treatment. Conclusion: The combination of rifampicin and isoniazid with three intermittent dosing regimens per week and once daily dosing regimen has comparable efficacy and safety in the treatment of newly diagnosed active pulmonary tuberculosis. Three intermittent dosing regimens per week can reduce the number of times patients take medication，improve treatment compliance，and are more suitable for clinical promotion and application.