Safety of Chemotherapy Regimens Containing Thioureidoiminomethylpyridinium Perchlorate in Pulmonary Tuberculosis with Multiple, Pre-Extensively and Extensively Drug Resistance

The objective: to evaluate safety profile when adding thioureidoiminomethylpyridinium perchlorate (Tpp) to anti-tuberculosis regimens during the intensive phase of treatment of pulmonary tuberculosis patients with MDR, pre-XDR and XDR. Subjects and Methods. Group Tpp+ consisted of 72 patients who completed a course of anti-tuberculosis therapy containing Tpp at a daily dose of 400 mg during the intensive phase of treatment. Group Tpp-included 50 patients who completed the intensive phase of anti-tuberculosis therapy containing no Tpp. Results. It has been confirmed that a large number of endocrine adverse reactions (AR) leading to hypothyroidism are due to inclusion of Tpp to the treatment regimen, but to a greater extent, its combination with other thyrotoxic drugs - protionamide and aminosalicylic acid. However, there was not a single case of hypothyroidism in the group where the above drugs were prescribed without Tpp. Among 72 (100%) patients who were prescribed drugs suspected of the thyrotoxic action, hypothyroidism developed in 21% of cases: when Tpp was prescribed – in 3%, when Tpp + aminosalicylic acid were prescribed – in 11%, when Tpp + prothionamide were prescribed – in 7%.