Health-related quality of life of patients with rifampicin-resistant/multidrug-resistant tuberculosis in Vietnam: a prospective follow-up study

<h2>ABSTRACT</h2><h3>Background</h3> Currently, the management of rifampicin-resistant/multidrug-resistant tuberculosis (RR/MDR-TB) primarily focuses on clinical characteristics and microbiological indicators. However, the disease also negatively impacts patients' psychological, economic, and social well-being. Thus, shifting our attention toward health-related quality of life (HRQOL) is essential. <h3>Method</h3> This was a prospective follow-up study conducted within government programmatic management of drug-resistant tuberculosis clinics in seven provinces of Vietnam. HRQOL was assessed at the baseline and after six months of treatment using the SF-36 version 2.0 questionnaire. <h3>Result</h3> A total of 180 patients with RR/MDR-TB completed the SF-36 version 2.0 survey at two time points. The physical component summary (PCS) scores at these two time points were 42.0 ± 8.4 and 44.2 ± 10.5, while the mental component summary (MCS) scores were 41.7 ± 9.0 and 49.8 ± 11.4, respectively. Following multivariable analysis, educational level and marital status were found to be associated with changes in PCS scores from baseline to six months of treatment. Conversely, age, comorbidity, and tuberculosis treatment category were related to changes in MCS scores. <h3>Conclusion</h3> Treatment for RR/MDR-TB has a positive impact on the HRQOL of patients. However, the PCS score after six months of treatment remained low. Therefore, incorporating appropriate exercise regimens, physical therapy measures, and rehabilitation strategies tailored to the needs and capabilities of each patient is essential to enhance their physical health.