Contribution of front-line, standard-of-care drugs to bactericidal responses, resistance emergence, and cure in murine models of easy- or hard-to-treat tuberculosis disease
Nathan Peroutka‐Bigus, Elizabeth J. Brooks, Michelle E. Ramey, Hope D’Erasmo, Jackie P. Ernest, Allison Bauman, Lisa K. Woolhiser, Radojka M. Savić, et al. (12 authors)
Antimicrobial Agents and Chemotherapy · 2025-03
Abstract
ABSTRACT By assessing the standard-of-care regimen for tuberculosis (TB) in BALB/c and C3HeB/FeJ mice, we demonstrate that rifampin, with or without pyrazinamide, is essential for an effective bactericidal response and suppression of resistance. Potency measurements in an in vitro lipid-rich model and a rabbit caseum assay recapitulate the significance of rifampin as a sterilizing agent. These outcomes align with clinical performance, thus emphasizing the value of in vitro predictive tools and murine TB models with human-like pathology.
MeSH terms
- Pyrazinamide
- Tuberculosis
- Potency
- Regimen
- Mycobacterium tuberculosis
- Medicine
- In vitro
- Disease
- Immunology
- Standard of care
- Pharmacology
- Microbiology
- Biology