Trends, challenges, and outcomes of extrapulmonary tuberculosis: a ten-year study in Cologne (2012-2022)

Background Extrapulmonary tuberculosis (EPTB) presents significant challenges in diagnosis and treatment and generally receives less attention than pulmonary tuberculosis (PTB). Methods We conducted a retrospective analysis of tuberculosis (TB) patients reported to the public health department of Cologne from 2012 to 2022 focussing on EPTB, its epidemiology, diagnostic methods, and treatment protocols, within a major German city. A subgroup analysis of EPTB patients (2012-2019, n = 254) examined diagnostic accuracy, treatment regimens, and adherence. Results Of 1,003 notified TB diagnoses, 33% (329/1,003) were identified as EPTB, with lymph nodes being the most frequently affected site. Mycobacterium tuberculosis was the predominant pathogen. EPTB was significantly more prevalent among individuals from countries with high TB incidence rates (41%, p 95% of patients, aligning to national guidelines. In contrast to declining PTB incidence, EPTB remained stable. Overall documented treatment success rate (79%) fell short of the WHO target (≥90%), underscoring the need for improved case management and reporting strategies. Conclusions Enhanced awareness, specialised care, and targeted interventions for migrant populations are critical to achieving global TB control objectives.