Evaluating the prognosis of pulmonary tuberculosis with a 320-detector row dual-input computed tomography perfusion

Background It is hard to evaluate the prognosis of chemotherapy for pulmonary tuberculosis (TB) lesions. The 320-detector row dual-input CT perfusion technique can provide a new way to predict the effect of treatment by analyzing the changes of perfusion parameters pre- and post-chemotherapy. Methods Thirty patients with TB were divided into 2 groups: the remission group (20 cases) and the non-remission group (10 cases). All patients underwent dual-input CT perfusion scan twice at before (1 week) and after (2 weeks) chemotherapy. Then, the perfusion data, including pulmonary flow, bronchial flow, were acquired. Results No significant lesion size changes were observed post-chemotherapy. Pretreatment pulmonary flow (57.8 ± 11.42 vs 29.44 ± 11.19 mL min⁻1·(100 mL)⁻1, P Conclusion The findings showed that the patients with high pulmonary blood flow of tuberculosis are relatively sensitive to chemotherapy and have a good prognosis. Changes in perfusion values after the treatment of pulmonary tuberculosis are related to recent therapeutic efficacy; an increase in BF values suggests the progression of the tuberculosis lesions and a poorer prognosis. And the CT perfusion can be applied to the effect of the TB therapy.