Population-Level Frequency of Fluoroquinolone Resistance by Whole-Genome Sequencing Drug Predictions in <i>Mycobacterium tuberculosis</i> Complex Isolates in England From 2017 Through 2023
Elena Ferran, Cathleen Chan, Noorann Sheikh, Martin Dedicoat, Eliza Alexander, Ana Lúıza Gibertoni Cruz, James Brown, Esther Robinson, et al. (9 authors)
Clinical Infectious Diseases · 2024-11
Abstract
Fluoroquinolones are increasingly important for anti-tuberculosis (TB) treatment. Identifying fluoroquinolone resistance (FR) is essential. Using sequencing data from over 16 000 unselected isolates, this first English survey of FR, found it present in 1.4% overall and 23.9% of multidrug-resistant TB. Routine sequencing allows clinically-relevant resistance surveillance and should be widely adopted.
MeSH terms
- Mycobacterium tuberculosis
- Medicine
- Tuberculosis
- Drug resistance
- Whole genome sequencing
- Microbiology
- Mycobacterium tuberculosis complex
- DNA sequencing
- Population
- Multiple drug resistance
- Virology