Frequency of Fluoroquinolone and Aminoglycoside Resistance Online Probe Assay in Multidrug-Resistant Tuberculosis Patients

Background: The resistance of tuberculosis to anti-tuberculous therapy is a severe public health concern all over the globe. The most common and important cause of resistance to anti-tuberculous therapy is poor patient compliance with or inappropriate therapy dosing. Objective: In order to evaluate the prevalence of resistance to commonly used 2nd-line anti-tuberculous drugs, an online probe assay was conducted among patients diagnosed with multi-drug-resistant tuberculosis. This study specifically focused on patients who were receiving treatment with fluoroquinolones and aminoglycosides and were seeking care at Lady Reading Hospital, a tertiary care facility located in Peshawar. Methods: This study was conducted at the Department of Pulmonology ward of Lady Reading Hospital, Peshawar, from Jan 2021 to Jan 2022, six months in which a total of 150 patients were observed to determine the frequency of common 2nd-line standard anti-tuberculous drugs resistance online probe assay in patients with multidrug-resistant tuberculosis. flouroquinolones and . Non-probability sequential sampling was the method used for sampling.