A rare cutaneous infection with <i>Mycobacterium chelonae</i> in a pediatric patient treated with trametinib for <i>KRAS</i>‐mutated diffuse glioma
Chenin Ryan, Angel Moore, Matthew J. Davis, Caitlin Yazel, Shabnam Momtahen, Angela Ricci, Elizabeth A. Talbot, Julianne A. Mann, et al. (9 authors)
Pediatric Dermatology · 2024-08
Abstract
Mitogen-activated extracellular signal-regulated kinase inhibitors (MEKi) represent a promising new therapy for pediatric patients with low-grade gliomas, which frequently have abnormal signaling within the mitogen-activated protein kinase (MAP kinase) pathway. However, understanding of long-term efficacy and toxicity is limited in pediatric glioma patients. This article describes a rare presentation of a widespread cutaneous infection with Mycobacterium chelonae in a pediatric patient with a low-grade glioma treated with trametinib.
MeSH terms
- Medicine
- Trametinib
- Glioma
- KRAS
- MAPK/ERK pathway
- Mycobacterium chelonae
- Kinase
- MEK inhibitor
- Cancer research
- Oncology
- Internal medicine