Successful Treatment of a Severe Vision-Threatening Paradoxical Tuberculous Reaction with Infliximab: First Pediatric Use
Abo YN, Curtis N, Butters C, Rozen TH, Marais BJ, Gwee A
The Pediatric infectious disease journal · 2020-04
Abstract
A 7-year-old girl with tuberculous (TB) meningitis developed optochiasmatic arachnoiditis, a vision-threatening paradoxical reaction, after starting TB treatment including adjunctive steroid therapy. She was treated with infliximab with complete recovery. This is the first report of the use of a tissue necrosis factor α inhibitor for the treatment of a severe paradoxical TB reaction in a child.
MeSH terms
- Humans
- Tuberculosis, Meningeal
- Arachnoiditis
- Antitubercular Agents
- Magnetic Resonance Imaging
- Treatment Outcome
- Severity of Illness Index
- Child
- Female
- Infliximab