Rifabutin central nervous system concentrations in a rabbit model of tuberculous meningitis
Sean Wasserman, Rosleine Antilus-Sainte, Noha Abdelgawad, Narineh M. Odjourian, Melissa Cristaldo, Maureen Dougher, Firat Kaya, Matthew Zimmerman, et al. (10 authors)
Antimicrobial Agents and Chemotherapy · 2024-07
Abstract
Tuberculous meningitis (TBM) has a high mortality, possibly due to suboptimal therapy. Drug exposure data of antituberculosis agents in the central nervous system (CNS) are required to develop more effective regimens. Rifabutin is a rifamycin equivalently potent to rifampin in human pulmonary tuberculosis. Here, we show that human-equivalent doses of rifabutin achieved potentially therapeutic exposure in relevant CNS tissues in a rabbit model of TBM, supporting further evaluation in clinical trials.
MeSH terms
- Rifabutin
- Rifamycin
- Tuberculous meningitis
- Meningitis
- Medicine
- Central nervous system
- Mycobacterium tuberculosis
- Antibiotics
- Tuberculosis
- Pharmacology
- Rifapentine
- Antibacterial agent
- Clinical trial
- Pharmacokinetics
- Immunology