Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia
Gunar Günther, Lusia Mhuulu, Azaria Diergaardt, Viola Dreyer, Maria Moses, Kaarna Anyolo, Nunurai Ruswa, Mareli Claassens, et al. (10 authors)
Emerging infectious diseases · 2024-02
Abstract
Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background regimen and adherence. The report highlights the risk for bedaquiline resistance development and the need for rapid drug-resistance testing.
MeSH terms
- Bedaquiline
- Tuberculosis
- Medicine
- Multiple drug resistance
- Drug resistance
- Regimen
- Intensive care medicine