TB Research

Implementation of the cascade of care for latent mycobacterium tuberculosis infection in people living with HIV/Aids

Silva KRD, Negri AC, Sano DK, Reis FP, Chaves CEV, Venturini J, Bertucci AA, Reis VSD, et al. (11 authors)

Revista gaucha de enfermagem · 2024-12

Abstract

Objective To describe the outcome indicators of implementing a cascade of care for latent Mycobacterium tuberculosis infection in people living with the human immunodeficiency virus. Method Cross-sectional study, carried out with people living with HIV, from 2022 to 2024, in a reference service in Campo Grande, Mato Grosso do Sul. It occurred after the implementation of the following work process: Identification of people at risk for investigation of Latent Tuberculosis Infection (LTBI); Test for LTBI; Exclusion of active TB cases; Treatment for LTBI; Adherence to treatment; and Completion of treatment. Data were analyzed using descriptive statistics, Chi-square test and Fisher's exact test. Results 735 people were monitored, of which 29.6% were indicated to start treatment for latent infection, and 32.5% started it. Treatment completion was higher in those who used the shortened regimen (90.2% versus 71.8%; p-value Conclusion The implementation of the cascade of care demonstrated that 1⁄3 of participants had an indication for treatment and expanded access to recommended treatment. The conclusion was greater with the shortened scheme. Adverse reactions were infrequent.

MeSH terms

  • Humans
  • AIDS-Related Opportunistic Infections
  • HIV Infections
  • Acquired Immunodeficiency Syndrome
  • Isoniazid
  • Antitubercular Agents
  • Cross-Sectional Studies
  • Adult
  • Middle Aged
  • Brazil
  • Female
  • Male
  • Medication Adherence
  • Latent Tuberculosis