Association of the Genotype of TNFα with the Efficiency of the Intensive Phase of Chemotherapy and Formation of the Sizes of Destruction Cavities in Patients with Pulmonary Tuberculosis
Balobanova NP, Alymenko MA, Valiev RS, Valiev NR, Safonov YA, Lipatov VA, Polonikov AV, Ragulina VA, et al. (10 authors)
Bulletin of experimental biology and medicine · 2024-11
Abstract
The interrelation between the TNFα gene polymorphism and the effectiveness of the intensive phase of chemotherapy in patients with pulmonary tuberculosis, as well as the formation of diameter of the sizes of destruction cavities was studied. It was revealed that the most adverse course of the disease and a high frequency of formation of destruction cavities are associated with the GG genotype of the TNFα gene.
MeSH terms
- Humans
- Tuberculosis, Pulmonary
- Tumor Necrosis Factor-alpha
- Antitubercular Agents
- Genotype
- Polymorphism, Single Nucleotide
- Adult
- Middle Aged
- Female
- Male