Analysis of Association Between Various Clinical Forms of Tuberculosis and SLC11A1 and IFNG Gene Polymorphisms in Individuals of Yakut Ethnicity

172 Yakut patients with confirmed tuberculosis (TB) were included to the study, exploring the possible association between polymorphisms in SLC11A1 and IFNG genes and various clinical forms of TB in patients of Yakut ethnicity. Distributions of single nucleotide polymorphisms (SNPs) were analyzed in Yakut patients, in SLC11A1 gene Asp543Asn locus, in IFNG gene 6000 and 8360C loci, in relation to disease extent, clinical progression pattern, culture test results, presence of necrotic cavities. No association was detected between polymorphisms in genes SLC11A1 (rs17235409) or IFNG (rs2430561, rs2069718) and disease localization, clinical form, culture test result, or clinical progression pattern in patients with TB.