Rifabutin central nervous system concentrations in a rabbit model of tuberculous meningitis
Wasserman S, Antilus-Sainte R, Abdelgawad N, Odjourian NM, Cristaldo M, Dougher M, Kaya F, Zimmerman M, et al. (10 authors)
Antimicrobial agents and chemotherapy · 2024-07
Abstract
Tuberculous meningitis (TBM) has a high mortality, possibly due to suboptimal therapy. Drug exposure data of antituberculosis agents in the central nervous system (CNS) are required to develop more effective regimens. Rifabutin is a rifamycin equivalently potent to rifampin in human pulmonary tuberculosis. Here, we show that human-equivalent doses of rifabutin achieved potentially therapeutic exposure in relevant CNS tissues in a rabbit model of TBM, supporting further evaluation in clinical trials.
MeSH terms
- Central Nervous System
- Animals
- Rabbits
- Mycobacterium tuberculosis
- Tuberculosis, Meningeal
- Disease Models, Animal
- Rifabutin
- Rifampin
- Antibiotics, Antitubercular
- Antitubercular Agents