Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia
Günther G, Mhuulu L, Diergaardt A, Dreyer V, Moses M, Anyolo K, Ruswa N, Claassens M, et al. (10 authors)
Emerging infectious diseases · 2024-03
Abstract
Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in a teenager in Namibia, despite an optimal background regimen and adherence. The report highlights the risk for bedaquiline resistance development and the need for rapid drug-resistance testing.
MeSH terms
- Humans
- Tuberculosis, Multidrug-Resistant
- Treatment Outcome
- Adolescent
- Namibia
- Diarylquinolines