TB Research

US Guidelines Fall Short on Short-Course Tuberculosis-Preventive Therapy

Sonya Krishnan, Richard E. Chaisson

Clinical Infectious Diseases · 2023-10

Abstract

The provision of tuberculosis-preventive therapy (TPT) to vulnerable populations is critical for global control. Shorter-course TPT regimens are highly effective and improve completion rates. Despite incorporation of 1 month of rifapentine and isoniazid into global guidelines, current US TPT guidelines do not include this as a recommended regimen, but should.

MeSH terms

  • Medicine
  • Rifapentine
  • Regimen
  • Isoniazid
  • Tuberculosis
  • Short course
  • Directly Observed Therapy
  • Intensive care medicine
  • Tuberculosis control
  • Chemoprophylaxis
  • Latent tuberculosis