Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs
Ismat Lotia‐Farrukh, Nathalie Lachenal, Malik M Adenov, Saman Ahmed, Yerkebulan Algozhin, Sylvine Coutisson, Epifanio Sánchez Garavito, Catherine Hewison, et al. (28 authors)
Clinical Infectious Diseases · 2023-08
Abstract
Among 43 pregnant women receiving multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment with bedaquiline and/or delamanid, 98% had favorable treatment outcomes. Of 31 continued pregnancies, 81% had live births with no reported malformations, and 68% of neonates had normal birth weights. Effective MDR/RR-TB treatment during pregnancy can improve maternal outcomes without harming neonates.
MeSH terms
- Medicine
- Bedaquiline
- Pregnancy
- Rifampicin
- Tuberculosis
- Multiple drug resistance
- Obstetrics
- Pediatrics