Coevolution of <i>furA</i> -Regulated Hyper-Inflammation and Mycobacterial Resistance to Oxidative Killing through Adaptation to Hydrogen Peroxide
Xin Fan, Bei Zhao, Weishan Zhang, Ning Li, Kaixia Mi, Beinan Wang
Microbiology Spectrum · 2023-06
Abstract
Mycobacterium tuberculosis ( Mtb ) causes human tuberculosis (TB), which has killed more people in human history than any other microorganism. However, the mechanisms underlying Mtb pathogenesis and related genes have not yet been fully elucidated, which impedes the development of effective strategies for containing and eradicating TB.
MeSH terms
- Biology
- Microbiology
- Mycobacterium tuberculosis
- Gene
- Inflammation
- Oxidative stress
- Reactive oxygen species
- Wild type
- Proinflammatory cytokine
- Immunology
- Tuberculosis