A Case Report on Organic Psychosis Induced by Antitubercular Drugs in A Young Female

Antitubercular drugs including rifampicin, isoniazid and pyrazinamide can cause rare but severe adverse effects involving the central nervous system. Neuropsychiatric side effects ranging from headache to psychosis have been reported. Early identification and management is crucial to improve outcomes. We report the case of a 26-year-old female with a history of tuberculosis who developed symptoms of organic psychosis after taking antitubercular drugs for 45 days. She presented with altered sensorium, seizures, sensory and memory loss. Diagnosis of drug-induced psychosis was made based on the temporal association and exclusion of other causes. Symptoms resolved after discontinuation of the culprit medications. Clinicians should be aware of neuropsychiatric adverse effects of antitubercular drugs which though rare can be serious. Timely diagnosis and withdrawal of the offending medications are needed to improve outcomes in such cases.