ADR assessment of isoniazid induced psychosis: Case report and review of literature

Tuberculosis ranks among the top 10 causes of death globally and stands as the primary cause attributed to a single infectious agent. Among all antitubercular drugs, Isoniazid is most important role in the management of pulmonary tuberculosis.Various neuropsychiatric adverse effects have been documented in association with the use of isoniazid, both in therapeutic and overdose scenarios. This case report describes a 68-year-old male with multiple health issues, including disseminated tuberculosis, developed drug-induced psychosis, likely due to isoniazid in his anti-tubercular therapy. This case underscores the challenges of psychiatric adverse effects in tuberculosis treatment and emphasizes the importance of prompt recognition and intervention.