Efficacy and safety of bedaquiline in treatment regimens in patients TB/HV co-infection in the Udmurt Republic

The objective : to evaluate the efficacy and safety of bedaquiline in new chemotherapy regimens in HIV-positive tuberculosis patients. Subjects and Methods . Treatment results of 60 patients with TB/HIV co-infection using treatment regimens containing bedaquiline were analyzed. Results. Patients with TB/HIV co-infection demonstrated poor adherence to treatment, so 46/60 (76.6%) patients did not complete the intensive phase of chemotherapy. The use of bedaquiline did not cause a critical prolongation of the QT according to ECG results, manifestations of arrhythmia, and it was well combined with ART. Sputum conversion (by culture) was registered in the following cases: by the end of the 2nd month of chemotherapy in 36/60 (60.0%) patients, by the end of the 6th month of chemotherapy – in 11/14 (78.6%) patients.