Effects of Alcohol and Tobacco Abuse on Multi-Drug Resistant Tuberculosis Treatment Outcome, Mongolia

Abstract: Alcohol and tobacco use, and drug resistance have become key issues in TB care in Mongolia. Although the use of alcohol and tobacco in patients with multi-drug resistant TB (MDR-TB) has been identified, the relationship between MDR-TB treatment outcomes, alcohol and tobacco use has not yet been studied. Aim of study: To study effects of alcohol and tobacco abuse on MDR-TB treatment outcome. Methods: This is randomly assigned case control study. Patients, who enrolled in MDR-TB short regimen between 2020 and 2021, were participated in the study. Alcohol and Nicotine dependence was assessed by Nicotine dependence standard scale and AUDIT scale. Results: Of the 64 MDR-TB patients, 55% were male and the mean age of participants was 38.07±1.75 years. Based on AUDIT, 78% and 22% patients were classified as low risky, harmful, high risk level of alcohol use (Cronbach`s alpha 0.936). Conclusion: Alcohol and tobacco abuse are higher among MDR-TB patients in Mongolia. Alcohol and Nicotine dependence associated with bad treatment outcome of MDR-TB in the country.