Mutations in <i>rv0678</i> Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis
Nicholas C. Poulton, Zachary A. Azadian, Michael A. DeJesus, Jeremy M. Rock
Antimicrobial Agents and Chemotherapy · 2022-08
Abstract
Tuberculosis (TB) is the leading cause of death from any bacterial infection, causing 1.5 million deaths worldwide each year. Due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) there have been significant efforts aimed at developing novel drugs to treat TB.
MeSH terms
- Bedaquiline
- Mycobacterium tuberculosis
- Tuberculosis
- Drug resistance
- Efflux
- Biology
- Mutation
- Medicine
- Microbiology