Novel MenA Inhibitors Are Bactericidal against <i>Mycobacterium tuberculosis</i> and Synergize with Electron Transport Chain Inhibitors
Bryan J. Berube, Dara Russell, Lina Castro, Seoung‐ryoung Choi, Prabagaran Narayanasamy, Tanya Parish
Antimicrobial Agents and Chemotherapy · 2019-04
Abstract
Mycobacterium tuberculosis is the leading cause of morbidity and death resulting from infectious disease worldwide. The incredible disease burden, combined with the long course of drug treatment and an increasing incidence of antimicrobial resistance among M. tuberculosis isolates, necessitates novel drugs and drug targets for treatment of this deadly pathogen.
MeSH terms
- Tuberculosis
- Mycobacterium tuberculosis
- Microbiology
- Pathogen
- Antimicrobial
- Drug resistance
- Infectious disease (medical specialty)
- Disease
- Drug
- Medicine
- Virology
- Immunology
- Biology