Syndrome de choc toxique menstruel

Background: Host response to M. tuberculosis (M.tb) infection leads to tissue destruction and impairs the ability of drugs to reach the bacteria. New anti-inflammatory adjuvant therapies could enhance bacterial clearance. Curcumin (diferuloylmethane) is a lipophilic phytochemical present in turmeric (Curcuma longa). Encapsulation of curcumin with polymers (NanoCurcuminTM) increased absorption and bioavailability of curcumin and is being investigated as host-directed therapies for the treatment various diseases. Methods and Results: We investigated the effect of free and encapsulated NanocurcuminTM on M.tb induced host inflammatory responses in M.tb infected J774 macrophages. Bacterial burden and cytokine levels were enumerated by standard microbiological and immunological methods. We utilized physiologically achievable levels of NanocurcuminTM (based on prior in vivo studies) and found a dose dependent decrease in the levels of TNF-α in M.tb infected J774 macrophages. Conclusions: NanoCurcumin™ can modulate TNF-α and could be utilized as a host-directed therapy to enhanced bacterial clearance and potentially shorten TB drug regimen.