Treatment outcomes among childhood extensively drug-resistant tuberculosis patients in Pakistan

Extensively drug-resistant (XDR) tuberculosis (TB), previously defined as that caused by Mycobacterium tuberculosis concurrently resistant to isoniazid, rifampicin, any fluoroquinolone (FQ) and at least one of the three second-line injectable (SLI) drugs (amikacin, kanamycin and capreomycin), is now defined as TB caused by M. tuberculosis concurrently resistant to isoniazid, rifampicin, any FQ and at least one additional group A drug (levofloxacin, moxifloxacin, bedaquiline and linezolid) [1, 2]. It is the most difficult to treat form of TB, with an overall treatment success rate ranging from 4% to 65% [3]. Like other forms of TB, XDR-TB affects people irrespective of their age, including children (age<14 years). Although children suffering from drug-resistant (DR)-TB have a diverse spectrum of disease and adverse events, and different psychosocial, developmental and educational needs than adults, still they are treated with the same regimen as that of the adult DR-TB patients. The previously conducted, very few studies among childhood XDR-TB patients (sample size ranged from eight to 37 patients) have reported a variable rate of successful treatment outcomes (81–100%) [4, 5]. Despite Pakistan being a high DR-TB burden country, initiation of programmatic management of DR-TB (PMDT) back in 2010 [6] and >30 PMDT units all over the country [3], there was a lack of information about treatment outcomes of childhood XDR-TB patients that country. Thus, this study was conducted to evaluate the treatment outcomes among childhood XDR-TB patients in Pakistan. Treatment outcomes of childhood XDR-TB patients in Pakistan are better than in adult patients but still disappointing <https://bit.ly/3rkQ9sw> The authors are thankful to the National TB Control Program, Islamabad for their help in data collection.