Putting the p(hosphor) in pyroptosis
Rastogi S, Evavold CL, Briken V
Cell host & microbe · 2022-12
Abstract
A recent study in Science found Mycobacterium tuberculosis inhibits pyroptosis of the host cell by secreting a phosphatase (PtpB). PtpB targets the plasma membrane to dephosphorylate PI4P and PI(4,5)P 2 , inhibiting recruitment of the pore-forming gasdermin D N-terminal fragment. Pyroptosis inhibition contributes to virulence, as ptpB-deficient Mtb is attenuated in mice.
MeSH terms
- Cell Membrane
- Animals
- Mice
- Mycobacterium tuberculosis
- Intracellular Signaling Peptides and Proteins
- Phosphate-Binding Proteins
- Pyroptosis