Mycobacterium tuberculosis hijacks ubiquitin to inhibit pyroptosis
Krause DS, Dikic I
Molecular cell · 2022-12
Abstract
Chai et al. 1 reveal that the eukaryotic-like effector protein PtpB from Mycobacterium tuberculosis (MTB) dephosphorylates phospholipid membrane proteins, which prevents membrane localization of cleaved gasdermin D, inhibiting pyroptosis and cytokine release by infected macrophages to enable MTB immune evasion.
MeSH terms
- Macrophages
- Mycobacterium tuberculosis
- Ubiquitin
- Cytokines
- Pyroptosis