TB Research

Linezolid for patients with multidrug-resistant tuberculosis/extensively drug-resistant tuberculosis in China

Zhang P, Tan J, Lin Y, Zhang H, Deng G, Chen X

Drug discoveries & therapeutics · 2022-04

Abstract

Linezolid has been one of the key anti-tuberculosis agents for the treatment of multidrug-resistant tuberculosis (MDR-TB)/extensively drug-resistant tuberculosis (XDR-TB). It used to be very expensive and was not covered by social insurance from local governments. Nevertheless, a growing number of patients in China received linezolid in their anti- MDR/XDR TB regimens over the past decade. Many scholars in China have reported their experience using linezolid to treat patients with MDR/XDR-TB. In view of this, existing evidence of the efficacy and safety of linezolid and problems faced by Chinese patients with MDR/XDR-TB are summarized here.

MeSH terms

  • Humans
  • Mycobacterium tuberculosis
  • Tuberculosis, Multidrug-Resistant
  • Antitubercular Agents
  • China
  • Extensively Drug-Resistant Tuberculosis
  • Linezolid