Pharmacodynamics and Bactericidal Activity of Bedaquiline in Pulmonary Tuberculosis
Michael A. Lyons
Antimicrobial Agents and Chemotherapy · 2021-12
Abstract
Bedaquiline is a diarylquinoline antimycobacterial drug and a key component of several regimens in clinical development for the treatment of tuberculosis (TB) but with ongoing phase 3 trials that include assessment of simplified dosing. A pharmacokinetic-pharmacodynamic model of bedaquiline Mycobacterium tuberculosis -killing kinetics in adults with pulmonary TB was developed to inform dose selection of bedaquiline-containing regimens.
MeSH terms
- Bedaquiline
- Medicine
- Pharmacodynamics
- Regimen
- Tuberculosis
- Pharmacokinetics
- Mycobacterium tuberculosis
- Pharmacology
- Pulmonary tuberculosis
- Clinical trial
- Internal medicine
- Antimycobacterial
- Culture conversion
- Drug
- Antibacterial agent
- Drug resistance
- Elimination rate constant