Reproducibility of the Ribosomal RNA Synthesis Ratio in Sputum and Association with Markers of Mycobacterium tuberculosis Burden
Emmanuel Musisi, Christian Dide-Agossou, Reem Al Mubarak, Karen Rossmassler, Abdul Wahab Ssesolo, Sylvia Kaswabuli, Patrick Byanyima, Ingvar Sanyu, et al. (17 authors)
Microbiology Spectrum · 2021-09
Abstract
This study takes a major next step toward practical application of a novel pharmacodynamic marker that we believe will have transformative implications for tuberculosis. This article follows our recent report in Nature Communications that an assay called the rRNA synthesis (RS) ratio indicates the treatment-shortening of drugs and regimens.
MeSH terms
- Sputum
- Mycobacterium tuberculosis
- Tuberculosis
- Ribosomal RNA
- Reproducibility
- Biology
- Medicine
- Computational biology