Structure-function relationships in substrate binding and catalysis in IGPS from <i>M. tuberculosis</i>
David W. Konas, Nina M. Goodey, Oshane Thomas, Joseph Lacap, Paige McFadden
Abstract
Indole-3-glycerol phosphate synthase (IGPS) catalyzes the indole-forming reaction in the multi-step bacterial tryptophan biosynthetic pathway. This pathway appears to be necessary for bacterial growth and it could represent a target for potential new anti-infective agents in the future. In order to realize this possibility, more detailed information about IGPS enzyme-substrate
MeSH terms
- Function (biology)
- Substrate (aquarium)
- Substrate specificity
- Chemistry
- Tuberculosis
- Catalysis
- Biophysics