Factors associated with mortality among patients with tuberculosis at Chaiyaphum hospital

Background: Tuberculosis (TB) is still remains as a leading cause of high morbidity and mortality worldwide. Identifying risk factors for mortality following diagnosis of TB is important to predict prognosis in tuberculosis patients and planning effective. The aim of this study was to identify the factors associated with mortality among patients with TB at Chaiyaphum hospital, Thailand. Methods: An unmatched case control study was conducted on 110 patients with TB who died during treatment (case group) and 220 patients with TB who survived during treatment (control group) at tuberculosis clinic of Chaiyaphum hospital during the period from 1stOctober 2016 to 30th September 2019. Data were collected from medical records. The data were analyzed using Chi square test, Fisher exact test, and calculating the odds ratio (OR) with 95% confidence intervals (95%CI). Results: The results showed that the factors associated with TB mortality included age > 60 years (OR = 1.94, 95%CI 1.18-3.20, p = 0.005), body mass index lower than 18.5 kg/m2 (OR = 4.52, 95%CI 2.68-7.69, p < 0.001), recurrent TB (OR = 2.32, 95%CI 1.03-5.18, p = 0.039), HIV co-infected (OR = 2.64, 95%CI 1.28-5.43, p = 0.003), and hepatitis (OR = 8.26, 95%CI 1.22-408.73, p = 0.044). Conclusions: This study recommended that health care providers should recognize and have special follow up of patients with TB who had HIV co-infected, age > 60 years, underweight, recurrent TB, and hepatitis.