COPD O-013 : Association between Vitamin D Level and Clinical Symptom in Patient with Chronic Obstructive Pulmonary Disease

Background Vitamin D deficiency is prevalent in patients with chronic obstructive pulmonary disease (COPD). The relationship between vitamin D and clinical symptoms in stable COPD has not been fully investigated. We aimed to explore the association between vitamin D sufficiency and clinical symptoms in stable COPD patients. Methods We performed a cross-sectional study using data between October 2015 and March 2019 from the COPD Lung Evolution (CLUE) Registry in Samsung Medical Center. Serum 25-hydroxy (25-OH) vitamin D levels measured at diagnosis with concurrent spirometry. Vitamin D sufficiency was defined as serum level ≥ 30ng/mL of 25-OH vitamin D. Results Of the 330 COPD patients, mean age was 70.8±8.5 years and 305 (92.4%) were male. Current or ex-smokers were 296 (89.7%) and 281 (85.2%) did not have vitamin D sufficiency. Patients without vitamin D sufficiency showed higher COPD assessment test (CAT) score compared to those with vitamin D sufficiency (17.14±8.56 vs. 13.08±8.15, p = 0.002 and 80.4% vs. 63.3% for CAT ≥ 10, p =0.008). Among CAT items, the patients without vitamin D sufficiency showed higher scores in sputum (p = 0.005), chest tightness (p = 0.014), dyspnea (p = <0.001), activity (p = 0.006) and energy (p = 0.010) than those with vitamin D sufficiency. The modified Medical Research Council ≥2 was more common in patients without vitamin D sufficiency than those with vitamin D sufficiency (37.4% versus 22.4%, p = 0.044). Conclusions COPD patients without vitamin D sufficiency had worse clinical symptom than those with vitamin D sufficiency.