Hyperuricemia in Patients taking Antituberculous Therapy

BACKGROUND: The study focuses on the hyperuricemia in patients taking anti tuberculous therapy. AIMS OF THE STUDY: 1. To evaluate the incidence of drug induced hyperuricemia in proved cases of pulmonary tuberculosis in patients on short term regimen of anti-tuberculous therapy in Coimbatore locality. 2. To study about the predisposing factors for drug induced hyperuricemia. 3. To study and evaluate the clinical features of drug induced hyperuricemia. PATIENTS AND METHODS: Our study included 109 patients taking anti tuberculous therapy who is suffereing from pulmonary tuberculosis. RESULTS: In our study we took cases suffering from hyperuricemia in patients taking antituberculous therapy. CONCLUSION: Even though drug induced hyperuricemia occurred in patients taking antituberculous therapy, Asymptomatic rise in serum enzymes are noted in 7.2% of patients. This is reverted back to normal by the end of intensive phase. Patients with obesity, old age group, men, high BMI, alcohol intake were more susceptible to drug induced hyperuricemia. Patients who had clinical signs and symptoms of hyperuricemia showed rise in serum uric acid in the intensive phase which will become normalizes after completion of intensive phase.