TB Research

Toward a Single-Dose Cure for Buruli Ulcer

Sangeeta Susan Thomas, Nitin Pal Kalia, Marie‐Thérèse Ruf, Gerd Pluschke, Kévin Pethe

Antimicrobial Agents and Chemotherapy · 2020-07

Abstract

A single dose of Q203 (Telacebec), a phase 2 clinical candidate for tuberculosis, eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer infection without relapse up to 19 weeks posttreatment. Clinical use of Q203 may dramatically simplify the clinical management of Buruli ulcer, a neglected mycobacterial disease.

MeSH terms

  • Buruli ulcer
  • Mycobacterium ulcerans
  • Medicine
  • Tuberculosis
  • Mycobacterium tuberculosis
  • Skin ulcer
  • Dermatology
  • Disease
  • Internal medicine