TB Research

Toward a single dose cure for Buruli ulcer

Sangeeta Susan Thomas, Nitin Pal Kalia, Marie‐Thérèse Ruf, Gerd Pluschke, Kévin Pethe

bioRxiv (Cold Spring Harbor Laboratory) · 2020-04

Abstract

Abstract A single dose of TELACEBEC (Q203), a phase 2 clinical candidate for tuberculosis, eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer infection without relapse up to 19 weeks post treatment. Clinical use of Q203 could dramatically simplify the clinical management of Buruli ulcer, a neglected mycobacterial disease.

MeSH terms

  • Buruli ulcer
  • Mycobacterium ulcerans
  • Tuberculosis
  • Medicine
  • Mycobacterium tuberculosis
  • Dermatology
  • Cutaneous tuberculosis
  • Disease