Acute kidney injury: an unexpected Isoniazid-related adverse event in a patient with Crohn's disease receiving prophylactic treatment for latent tuberculosis

We have recently observed a case of acute kidney Injury (AKI) in a patient with Crohn's disease (CD) receiving isoniazid (INH) prophylaxis for latent tuberculosis infection (LTBI). While the most common INH-related adverse events are well-known and include asymptomatic elevation of serum liver enzyme concentrations, peripheral neuropathy and hepatotoxicity, INH-induced AKI is a very rare event that has been occasionally reported in the literature particularly in pediatric patients [ 1 Sakashita K Murata K Takahashi Y et al. Case Series of Acute Kidney Injury During Anti-tuberculosis Treatment. Intern Med. 2019; 58: 521-527 Crossref PubMed Scopus (10) Google Scholar , 2 Brik R Magen D Ben-Yzhak O et al. Isoniazid-induced crescentic glomerulonephritis in a child with a positive tuberculin skin test. Am J Nephrol. 1998; 18: 430-432 Crossref PubMed Scopus (7) Google Scholar , 3 Trainin EB Turin RD Gomez-Leon G Acute renal insufficiency complicating isoniazid therapy. Int J Pediatr Nephrol. 1981; 2: 53-54 PubMed Google Scholar ].