TB Research

Eosinophilia Induced Acute Interstitial Nephritis: A Case Report

Lakshya Yadav, Rajinder Sharma, Ritu Kaushik, Riya Dave

Indian Journal of Public Health Research & Development · 2022-04

Abstract

Introduction: This report presents the case of a patient with tubulointerstitial nephritis (ATIN) due toEosinophilia, situation that has not been reported in India.Case Presentation: A male patient with a history of pulmonary tuberculosis treated with ATT developedacute kidney injury. On admission, no evidence of abnormalities or history to explain the injury wasfound, but he did present tubular acidosis and associated Fanconi syndrome. The kidney injury wastemporarily consistent with ATT use, and a kidney biopsy confirmed ATIN. The drug was suspended,resulting in improved kidney function.Discussion: ATIN as a side effect of rifampin is a scarcely reported disease. The risk of developing thiscondition should be considered when starting and restarting treatments with this medication.Conclusion: ATIN is one of the side effects of tuberculosis treatment. Albeit rare, it should be consideredwhen starting tuberculosis medications.

MeSH terms

  • Medicine
  • Acute kidney injury
  • Tuberculosis
  • Eosinophilia
  • Renal function
  • Interstitial nephritis
  • Internal medicine
  • Kidney