Association between TLR2 Arg677Trp polymorphism and tuberculosis susceptibility: A meta-analysis

Background Toll-like receptor 2 (TLR2) is an important member of TLRs, which is significant in the initial of inflammatory response against bacteria. Several studies have been conducted to investigate the TLR2 Arg677Trp polymorphism and Tuberculosis (TB) susceptibility. Unfortunately, the results of previous studies were inconsistent. Objectives The aim of present study was to investigate the relationship between TLR2 Arg677Trp polymorphisms and TB susceptibility. Methods The association between the TLR2 Arg677Trp polymorphism and TB susceptibility was assessed by odds ratios (OR) together with their 95% confidence intervals (95%CI). Results Six case-control studies were enrolled in the meta-analysis. Overall, significant association between TLR2 Arg677Trp polymorphism and TB risk were found neither under allele contrast (C vs. T: OR = 0.59, 95%CI = 0.28-1.23, P = 0.158) nor under recessive genetic model (CC vs. CT/TT: OR = 0.43, 95%CI = 0.12-1.51, P = 0.188). Conclusion We conclude that TLR2 Arg677Trp polymorphism is not associated with TB susceptibility.