Vitamin D receptor gene polymorphism and tuberculosis

In recent years, the global situation of tuberculosis disease has deteriorated sharply, and the susceptibility of host to mycobacterium tuberculosis is heterogeneous.Therefore, polymorphism of gene loci plays an important role in the susceptibility to tuberculosis.Vitamin D receptor(VDR)gene has been confirmed as one of the major candidate genes for genetic susceptibility to tuberculosis.The four well-studied major sites are Foki, Bsmi, Apai and Taqi.However, the specific mechanism by which polymorphism affects the occurrence and development of tuberculosis has not been fully elucidated.There is considerable controversy about the relationship between VDR gene polymorphism and tuberculosis susceptibility, mainly due to the interaction between environment and genes, racial differences, etc.This article reviews the polymorphism of VDR gene and its effect on host infected tuberculosis. Key words: Vitamin D receptor; Gene polymorphism; Tuberculosis