TB Research

X-Linked Hyper IgM Syndrome Presenting with Recurrent Tuberculosis-a Case Report

Krishnan VP, Taur P, Pandrowala A, Madkaikar M, Desai M

Journal of clinical immunology · 2020-01

Abstract

The hyper IgM syndromes are a group of rare primary immunodeficiency disorders. Currently 6 classes of HIGM are described. X-linked HIGM is also called the type 1 HIGM is the commonest variant in which children present in early infancy with features of combined immunodeficiency. Tuberculosis is a very rare presentation as a presenting symptom in HIGM. Here, we describe a child with XHIGM with recurrent tuberculosis.

MeSH terms

  • Humans
  • Tuberculosis, Pulmonary
  • Respiratory Insufficiency
  • Recurrence
  • Tomography, X-Ray Computed
  • Skin Tests
  • Child, Preschool
  • Infant
  • Male
  • X-Linked Combined Immunodeficiency Diseases
  • Hyper-IgM Immunodeficiency Syndrome, Type 1
  • Image-Guided Biopsy