Principles of Rational Chemotherapy for Tuberculosis

e key reasons for development of drug-resistant M. tuberculosis are prescription of inadequate chemotherapy regimens, early discontinuation and/or interruptions of chemotherapy, lack in both range and amounts of necessary drugs, use of the drugs of substandard quality. is article highlights basic principles of rational chemotherapy for TB, including adherence to clinical guidelines, prescription of drugs with due regard to information in package lea ets.