Successful Systemic and Topical Treatment of Mycobacterium abscessus Otomastoiditis
Floor van Wijk, Jérôme J. Waterval, Koen van Aerde, Stefanie Henriet, Fons Meijer, Lennaert C. Borra, Rob E. Aarnoutse, Jakko van Ingen
Antimicrobial Agents and Chemotherapy · 2019-10
Abstract
Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intravenous imipenem and tigecycline, and oral clofazimine and azithromycin and adjunctive surgery. This structured approach led to cure, with 1 year of follow-up after treatment.
MeSH terms
- Tigecycline
- Medicine
- Clofazimine
- Mycobacterium abscessus
- Azithromycin
- Imipenem
- Regimen
- Antibacterial agent
- Clarithromycin
- Antibiotics
- Linezolid
- Surgery
- Dermatology