Acquisition of Cross-Resistance to Bedaquiline and Clofazimine following Treatment for Tuberculosis in Pakistan
Arash Ghodousi, Alamdar Hussain Rizvi, Aiman Baloch, Abdul Ghafoor, Faisal Masood Khanzada, Mehmood Qadir, Emanuele Borroni, Alberto Trovato, et al. (10 authors)
Antimicrobial Agents and Chemotherapy · 2019-06
Abstract
We report on the first six cases of acquired resistance to bedaquiline in Pakistan. Seventy sequential isolates from 30 drug-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing and by the detection of mutations in relevant genes. We documented cases failing therapy that developed specific mutations in Rv0678 and had increased MICs associated with cross-resistance to clofazimine during treatment.
MeSH terms
- Bedaquiline
- Clofazimine
- Tuberculosis
- Drug resistance
- Medicine
- Cross-resistance
- Acquired resistance
- Microbiology
- Biology