TB Research

Draft Genome Sequences of 12 <i>Mycolicibacterium smegmatis</i> Strains Resistant to Imidazo[1,2- <i>b</i> ][1,2,4,5]Tetrazines

Aleksey A. Vatlin, К. В. Шур, В. Н. Даниленко, Dmitry A. Maslov

Microbiology Resource Announcements · 2019-04

Abstract

Here, we report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2- b ][1,2,4,5]tetrazines, which are antituberculosis drug candidates. We have identified 7 different mutations in the MSMEG_1380 gene, which encodes the AcrR/TetR_N transcriptional repressor, which may activate efflux-mediated resistance.

MeSH terms

  • TetR
  • Mycobacterium smegmatis
  • Efflux
  • Repressor
  • Gene
  • Genome
  • Mutant
  • Genetics
  • Biology
  • Computational biology