Draft Genome Sequences of 12 <i>Mycolicibacterium smegmatis</i> Strains Resistant to Imidazo[1,2- <i>b</i> ][1,2,4,5]Tetrazines
Aleksey A. Vatlin, К. В. Шур, В. Н. Даниленко, Dmitry A. Maslov
Microbiology Resource Announcements · 2019-04
Abstract
Here, we report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2- b ][1,2,4,5]tetrazines, which are antituberculosis drug candidates. We have identified 7 different mutations in the MSMEG_1380 gene, which encodes the AcrR/TetR_N transcriptional repressor, which may activate efflux-mediated resistance.
MeSH terms
- TetR
- Mycobacterium smegmatis
- Efflux
- Repressor
- Gene
- Genome
- Mutant
- Genetics
- Biology
- Computational biology