Mitochondrial Damage and Drp1 Overexpression in Rifampicin- and Isoniazid-induced Liver Injury Cell Model
Fangfang Li, Juan Zhou, Yi Li, Kewei Sun, Jun Chen
Journal of Clinical and Translational Hepatology · 2019-03
Abstract
Background and Aims: Rifampicin (RFP) and isoniazid (INH) are widely used as anti-tuberculosis agents. However, the mechanisms underlying the involvement of reactive oxygen species and mitochondria in RFP- and INH-related hepatotoxicity have not been established yet. This study aimed to observe the intracellular mechanisms leading to mitochondrial dysfunction and morphological changes in RFP- and INH-induced hepatocyte injury.
MeSH terms
- Rifampicin
- Isoniazid
- Medicine
- Intracellular
- Mitochondrion
- Hepatocyte
- Tuberculosis
- Liver injury
- Reactive oxygen species
- Pharmacology